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Metin Sokmen, MD
25 Ağu 20241 dakikada okunur
Ageing-related Bone and Immunity Changes: Insights Into the Complex Interplay Between the Skeleton and The Immune System
🔹Aging causes a decline in bone mineral density (BMD) and alters bone microarchitecture, leading to weakened bones. This is due to...
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Metin Sokmen, MD
25 Ağu 20241 dakikada okunur
Oxidative Stress and Aging: Synergies for Age Related Diseases
🔹Aging is a natural, progressive decline in physiological function, which increases the vulnerability of cells and tissues to oxidative...
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Metin Sokmen, MD
25 Ağu 20241 dakikada okunur
Are immunosenescent T cells really senescent?
🔹The increasing incidence of age-related diseases, such as Alzheimer's, diabetes, cardiovascular disease, and cancer, which are linked...
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Metin Sokmen, MD
25 Ağu 20242 dakikada okunur
Targeting Vascular Senescence in Cardiovascular Disease with Aging
🔹Vascular Aging and Cardiovascular Diseases: Aging leads to significant arterial changes, including increased arterial stiffness and...
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Metin Sokmen, MD
25 Ağu 20242 dakikada okunur
Gut Microbiota and Healthy Longevity
🔹 Gut Microbiota and Longevity: The gut microbiota's composition significantly differs between long-lived species and their...
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Metin Sokmen, MD
25 Ağu 20241 dakikada okunur
The Emerging Importance of Lymphangiogenesis in Aging and Aging-Associated Diseases
🔹Lymphatic aging represented by cellular and functional changes is an increased risk factor for geriatric disorders. 🔹Advanced age and...
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Metin Sokmen, MD
25 Ağu 20241 dakikada okunur
Microbiota-Bone Axis in Ageing-Related Bone Diseases
🔹Bone health relies on a balance between bone formation by osteoblasts and resorption by osteoclasts. Aging can disrupt this balance,...
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Metin Sokmen, MD
25 Ağu 20241 dakikada okunur
Metabolic Changes in Cardiac Aging
🔹Cardiac aging is a natural process characterized by cardiomyocyte hypertrophy and dysfunction. 🔹Energy Metabolism Transformation* -...
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Metin Sokmen, MD
25 Ağu 20241 dakikada okunur
Guidelines for Minimal Information on Cellular Senescence Experimentation in vivo
🔶Brain: 🔹Both proliferative glial cells and post-mitotic neurons can be positive for markers of cellular senescence. 🔹Markers like...
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Metin Sokmen, MD
25 Ağu 20242 dakikada okunur
Phytonutrients in the Promotion of Healthspan: A New Perspective
🔹Diet and nutrition play pivotal roles in modulating aging processes, and plant-based diets rich in bioactive phytonutrients may help...
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Metin Sokmen, MD
25 Ağu 20242 dakikada okunur
The Untapped Potential of Cold Water Therapy as Part of a Lifestyle Intervention for Promoting Healthy Aging
🔹Hydrotherapy has been used for centuries, with roots in ancient civilizations such as Egypt and China. 🔹Historical figures like...
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Metin Sokmen, MD
25 Ağu 20241 dakikada okunur
Transforming Obesity: The Advancement of Multi-Eeceptor Drugs
Mechanisms of GLP-1-Based Drugs: The regulation of body weight involves complex interactions between the brain and adipose tissue,...
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Metin Sokmen, MD
7 Ağu 20241 dakikada okunur
Biological Resilience in Health and Disease
An overview of the study is summarized in the attached image. Here, I am including the relevant box information from the article that...
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Metin Sokmen, MD
7 Ağu 20241 dakikada okunur
Nur77 Improves Ovarian Function in Reproductive Aging Mice by Activating Mitophagy and Inhibiting Apoptosis
*Reproductive aging not only affects the fertility and physical and mental health of women but also accelerates the aging process of...
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Metin Sokmen, MD
7 Ağu 20242 dakikada okunur
LINE-1 Transposable Element Renaissance in Aging and Age-related Diseases
*Transposable elements (TEs) are essential components of eukaryotic genomes and subject to stringent regulatory mechanisms to avoid their...
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Metin Sokmen, MD
7 Ağu 20241 dakikada okunur
Achilles' Spear: A New Therapeutic Target for Age-related Diseases
*During cellular senescence, there is a marked activation of SASP components. *Apoptosis is a cellular fate quite distinct from cellular...
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Metin Sokmen, MD
7 Ağu 20241 dakikada okunur
Pivotal Role of AGE-RAGE Axis in Brain Aging with Current Interventions
*Microglial activation triggers inflammatory cascades in the brain, resulting in demyelination and white matter lesions, often...
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Metin Sokmen, MD
7 Ağu 20241 dakikada okunur
MAMs and Mitochondrial Quality Control: Overview and Their Role in Alzheimer’s Disease
Membrane-enclosed organelles are a crucial characteristic of eukaryotic cells, facilitating the compartmentalization of specific...
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Metin Sokmen, MD
7 Ağu 20242 dakikada okunur
Pathological Mechanisms of Kidney Disease in Ageing
Hallmarks of kidney ageing Genomic Instability, Telomere Shortening, and Epigenetic Alterations These are classified as 'primary'...
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Metin Sokmen, MD
7 Ağu 20242 dakikada okunur
Targeting neuronal epigenomes for brain rejuvenation
Neuron-specific epigenetic patterns are profoundly altered in the aged brain, contributing to impaired gene regulation and ultimately...
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