An overview of the study is summarized in the attached image. Here, I am including the relevant box information from the article that caught my attention.
*Naked mole rats are known to be the longest-living rodents, with a
maximum lifespan of 30 years, which is five times their predicted lifespan
based on their body size alone.
*Strikingly, this extreme longevity is accompanied by exceptional resistance to stress and disease, making this unconventional species a powerful resource to uncover novel resilience mechanisms.
*Studies using this long-lived model are increasingly uncovering novel molecular mechanisms that can protect cells against cellular damage.
*Consistent with the notion that somatic DNA mutations are linked to ageing, singlecell whole-genome sequencing has revealed that naked mole rat cells have a higher capacity to maintain genome sequence integrity of both spontaneous and bleomycin-induced somatic mutations than shorterlived species.
*In part, this might be due to their expression of evolutionarily distinct DNA-damage repair factors, such as the DNA double-strand break (DSB)-repair factor SIRT6.
*Naked mole rats also produce unique high-molecular-mass versions of major ECM components, such as a high-molecular-mass version of hyaluronic acid (HMM-HA), that are anti-inflammatory and protect against oxidative stress.
*Together with increased expression of longevity-associated genes and tumour suppressor genes within aged tissues, this is probably why naked mole rats are particularly disease-resistant.
*Promisingly, expression of naked mole rat resilience genes in rodents
with shorter lifespans can confer increased stress resistance.
*For example, overexpression of the naked mole rat version of hyaluronan
synthase 2 (Has2) promotes increased cancer resistance and longevity
in mice.
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